Historical overview of psychoactive mushrooms
Inflammation and Regeneration – January 01, 2009
Source: OpenAlex
Summary
Psychoactive drugs like psilocybin and psilocin show high therapeutic efficiency for obsessive-compulsive disorder, a challenging nervous disease. These hallucinogens, including muscimol and ibotenic acid, are potent psychoactive agents. Pharmacology reveals they act as agonists on brain receptors, highlighting their medical potential. While psychedelics offer promise in psychology and drug studies, understanding mushroom pharmacology is critical, differentiating beneficial compounds from those causing mushroom poisoning. Research into chemical synthesis and alkaloids, including potential antidotes like Silymarin, expands our medical knowledge.
Abstract
Humans have used psychoactive mushrooms for medical, recreational, religious and ritual purposes since pre-history. Previous studies have clarified that psychoactive mushrooms produce psychoactive agents such as psilocybin, psilocin, ibotenic acid, and muscimol. However, the status of psychoactive mushrooms in most countries as illegal hallucinogens has prevented full investigation of their biochemical properties. Recent studies have shown that many psychoactive agents pass through the blood-brain barrier and act on neurotransmitter receptors. Psilocybin and psilocin are 5-HT1A and 5-HT2A/C receptor agonists, respectively, while ibotenic acid is a glutamic acid receptor agonist and muscimol is a GABAA receptor agonist. A new psychoactive agent, aeruginascin, has also been isolated from psychoactive mushrooms, and it is expected that more useful compounds will be discovered as the technology of component analysis advances. In addition, it has been shown that psilocybin and psilocin have high therapeutic efficiency for obsessive-compulsive disorder, which is a difficult-to-treat nervous disease. The increase of nervous diseases in modern society has thus given new importance to psychoactive mushrooms. In this review, we summarize the history of the use of psychoactive mushrooms, from pre-history to the modern age, describe their classification and distribution, survey previous studies, and discuss their therapeutic effects for difficult-to-treat nervous disease. The utilization and distribution of psychoactive mushrooms in Japan is given special attention, as there are few articles on this subject.