The constituents of Gymnopilus spectabilis.
Chemical and Pharmaceutical Bulletin – January 01, 1986
Source: OpenAlex
Summary
Surprisingly, the hallucinogenic mushroom *Gymnopilus spectabilis* yielded no psilocybin in analyzed collections, despite its reputation. Instead, detailed chemistry revealed cerevisterol, ergosterol, and ergosteryl peroxide. A new acetylenic compound, 4, 6-decadiyne-1, 3, 8-triol, was also characterized, highlighting complex fungal biology. While other Japanese mushrooms contain psilocybin, this finding challenges assumptions about the mushroom's psychedelic properties. Understanding the stereochemistry of these compounds contributes to drug studies and potential chemical synthesis, expanding knowledge beyond traditional medicine's focus on known alkaloids.
Abstract
Cerevisterol (1) and a new acetylenic compound, 4, 6-decadiyne-1, 3, 8-triol (2) were isolated and characterized from a hallucinogenic mushroom, Gymnopilus spectabilis (FR.) A. H. SMITH, along with ergosterol, ergosteryl peroxide and choline.Psychoactive compounds such as psilocybin and related compounds have not been detected in our collections of this mushroom, though some psilocybin has been found in several other Japanese mushrooms.