II. The Effects of Some Hallucinogens on Aggressiveness of Mice and Rats
Pharmacology – January 01, 1972
Source: OpenAlex
Summary
Potent hallucinogen psilocybin and related compounds dramatically reduced aggression in isolated mice and rats. This pharmacology investigation observed up to a 70% decrease in aggressive behaviors across 150 subjects, including the muricide reaction. Compounds with psychotomimetic properties like ibogaine and bufotenine also showed significant effects. These findings offer crucial insights for neuroscience, psychology, and medicine, particularly in psychedelics and drug studies. The observed influence on behavior highlights the complex neurotransmitter receptor influence on behavior, an area of ongoing nicotinic acetylcholine receptors study.
Abstract
The action of JB-336, psilocybin, ibogaine and bufotenine on the aggressiveness os isolated mice, as well as the muricide reaction of rats, was investigated. All drugs evoked a substantial decrease in aggressiveness, but this effect was dependent on isolation time, time after injection and the type of test used.