Central Aromatic Amine Levels and Behavior
Archives of Neurology – July 01, 1963
Source: OpenAlex
Summary
The profound impact of biogenic amines like Serotonin on behavior is a core focus in Psychology and Drug Studies. Pharmacology reveals how agents modulate these crucial compounds. For instance, Reserpine depletes amines, while Monoamine oxidase inhibitors prevent their destruction. Hallucinogens, including Lysergic acid diethylamide and Psilocybin, influence Neurotransmitter Receptor Influence on Behavior by blocking or mimicking amine actions. The intricate Chemistry, from Phenothiazines and Benzothiazines Synthesis and Activities to broader amine applications, underpins diverse brain manipulations.
Abstract
Introduction The significance to behavior of biologically active amines normally present in the mammalian brain has been receiving increased attention by workers in diversified fields in recent years. This trend has been accelerated by the recognition that a number of potent psychotherapeutic agents seem to assert their beneficial effects by influencing these amines in various ways. For example, the tranquillizing agent reserpine is thought to act by depleting the brain of norepinephrine, serotonin, and possibly other amines,3,9while the psychic energizing monoamine oxidase inhibitors are thought to act by hindering their destruction.4Phenothiazines are known to block both peripheral and central effects of a number of amines, presumably by competing for receptor sites. Hallucinogenic agents such as lysergic acid diethylamide (LSD-25) and psilocybin also block certain effects of various amines, but many have the additional property of mimicking the actions of other amines. Relationships between hallucinogenic agents, psychoactive