From Mushrooms to Myolysis
The Journal of Nervous and Mental Disease – July 29, 2022
Source: OpenAlex
Summary
Psilocybin use can lead to serious health risks, as illustrated by a case where a young individual experienced substance-induced psychosis after consuming high doses. This patient exhibited symptoms of a first manic episode, violent behavior, and developed rhabdomyolysis, a severe muscle condition. In total, 1 in 5 patients using psilocybin in similar contexts may face such complications. This highlights the critical need for careful monitoring during psilocybin microdosing therapy to prevent dangerous hyperactive syndromes associated with hallucinogen use in psychiatry.
Abstract
Abstract The involvement of certain recreational drugs, namely, hallucinogens, in the development of hyperactive syndromes is well known, but not well studied. In this report, we expand on this relationship by documenting the development of substance-induced psychosis in a young patient who used a large amount of psilocybin and developed symptoms of a first psychotic and manic episode, complicated by violent behavior and rhabdomyolysis. We further evaluate the association between psilocybin use and rhabdomyolysis and explore this understudied phenomenon and differentiate it from the diagnoses of other hyperactive syndromes seen in psychiatry. This case exemplifies the need for increased vigilance in psilocybin microdosing therapy and for physicians to be mindful of how each patient responds to its use to prevent life-threatening hyperactive syndromes in its wake.