Overview Of Review (OoR) on PSILOCYBIN in Psychiatric Disorders
OpenAlex – August 04, 2024
Source: OpenAlex
Summary
Psilocybin, a potent Hallucinogen, holds significant promise for mental health. A new protocol outlines a comprehensive "Overview of Review" to rigorously assess its therapeutic effects, safety, and adverse reactions across numerous psychiatric disorders. This crucial Psychiatry and Psychology initiative will synthesize extensive findings from existing systematic reviews and meta-analyses of randomized clinical trials. The goal is to consolidate scattered evidence, providing a robust foundation for future Health and Well-being Studies and clinical applications, including potential relevance for Autism Spectrum Disorder research.
Abstract
eview question / Objective This protocol outlines the methodology for an "Overview of Review" (OoR) study which aims to conduct a comprehensive analysis of systematic reviews with meta-analyses of psilocybin randomized clinical trials.The primary objective is to provide an evaluation of the therapeutic effects, safety profiles, and adverse effects of psilocybin as documented in the best evidence available.: P (Population): Patients included in systematic reviews who have undergone psilocybin therapy for various clinical indications (DSM-5-TR or ICD-10 Disorders) **I (Intervention)**: Psilocybin therapy.C (Comparison): placebo, no treatment, or other standard drug or no drug therapies O (Outcomes): 1. Therapeutic effects of psilocybin (efficacy).2. Acceptability and tolerability of psilocybin therapy 3. Prevalence and severity of adverse effects associated with psilocybin therapy (safety profile). RationaleThe motivation for this study arises from the recent surge in interest in psilocybin therapy and the need to consolidate the growing body of findings, which at the moment constitute scattered evidence.Psilocybin, a naturally occurring psychedelic compound found in certain species of mushrooms, has garnered significant scientific and therapeutic interest in recent years.Given the p o t e n t i a l s i g n i fi c a n c e o f p s i l o c y b i n i n revolutionizing mental health treatment and our understanding of consciousness, along with the rapidly evolving research landscape, this overview of reviews is timely and crucial.It aims to provide a comprehensive, evidence-based assessment of the current state of psilocybin research, which could inform future clinical applications, research directions, and policy decisions.Condition being studied Psilocybin therapy in subjects diagnosed with psychiatric disorders according to international diagnostic criteria such as the ICD-10 and DSM-5-TR.