Hallucinogen Persistent Perception Disorder Induced by New Psychoactive Substituted Phenethylamines; A Review with Illustrative Case
Current Psychiatry Reviews – August 10, 2016
Source: OpenAlex
Summary
The first documented case of Hallucinogen Persistent Perception Disorder (HPPD) caused by a high dose of 2C-E, a modern designer drug, highlights an emerging concern in Psychiatry. While HPPD is known from traditional psychoactive substances like Lysergic acid diethylamide, Psilocybin (a Tryptamine), and Mescaline, this Phenethylamine-class substance presents new challenges for Medicine. The individual's persistent visual disturbances, a focus of Psychology and Psychedelics and Drug Studies, were effectively blunted by lamotrigine. This case, often identified via Forensic Toxicology and Drug Analysis, signals evolving risks from novel hallucinogens.
Abstract
Hallucinogen Persistent Perception Disorder (HPPD) is considered an “uncommon” disorder described in association with use of hallucinogens such as LSD, mescaline and psilocybin. Despite multiple mentions of persistence of visual disturbances reported by users on online forums, clinicians may not be aware of this complication. There have been few descriptions of HPPD in association with use of new psychoactive substances (such as 2C-E). Increasing use of these designer stimulants places greater numbers at risk for psychiatric morbidities including HPPD. Here we report the first documented case of HPPD due to high dose 2C-E and blunting of symptoms with addition of lamotrigine. Keywords: Stimulants, hallucinogen, psychoactive, phenylethylamines.