Active Constituents of Psilocybin Mushroom Edibles
JAMA Network Open – September 11, 2025
Source: OpenAlex
Summary
Many unregulated psilocybin mushroom edibles contain no psilocybin. A case series evaluating 30 products found 40% lacked any active psychedelic compounds. Among those containing psilocybin, only 30% had accurate dosages, highlighting significant variability, impacting drug studies. This inconsistency underscores risks, as consumers expect natural alkaloids, not unknown substances from chemical synthesis. Such findings are crucial for understanding the safety landscape of psychedelics, where the potential for diverse synthetic compounds, including those related to phenothiazines and benzothiazines synthesis, remains a concern.
Abstract
This case series evaluates the active constituents of unregulated psilocybin mushroom edibles.