Psilocybin in Alcohol Use Disorder Maintains Abstinence Efficacity: A Scoping Review
Preprints.org – October 17, 2025
Source: OpenAlex
Summary
Psilocybin, a psychedelic alkaloid, shows promise in reducing alcohol cravings, a key behavior in alcohol use disorder. Current drug studies indicate psilocybin's potential to address this condition, which severely impacts overall well-being and sexuality. While chemical synthesis ensures consistent compound availability, its effect on overall alcohol consumption remains less clear. Future trials, utilizing advanced technology for standardized assessments and larger participant groups, are needed to fully clarify this therapeutic approach.
Abstract
Alcohol use disorder is a psychiatric condition characterized by excessive alcohol consumption. The drugs that are used to treat it often fail to prevent relapse. At the same time, psilocybin is increasingly being investigated for the treatment of various substance use disorder. This review aims to evaluate the results of the most recent clinical trials assessing psilocybin as a treatment for alcohol use disorder. According to these trials, psilocybin seems to reduce craving but its effect on overall alcohol consumption is less clear. There is no doubt that future trials would benefit from larger sample sizes and standardized tests.