Molecular targets of psychedelic‐induced plasticity
Journal of Neurochemistry – November 06, 2021
Source: OpenAlex
Summary
Psychedelics are rapidly gaining recognition for their therapeutic potential, particularly for antidepressant action, by engaging the serotonin 5-HT2A receptor. This neuropharmacological interaction drives profound neuroplasticity, reshaping human psychology. Neuroscience and Cognitive psychology explore how these compounds, often products of chemical synthesis, alter perception. While Biochemical Analysis and Sensing Techniques identify specific impacts on brain circuits, ongoing Psychedelics and Drug Studies are rigorously quantifying effect sizes and participant responses, aiming to translate this plasticity into lasting mental health benefits.
Abstract
Abstract Psychedelic research across different disciplines and biological levels is growing at a remarkably fast pace. In the prospect of a psychedelic drug becoming again an approved treatment, much of these efforts have been oriented toward exploring the relationship between the actual psychedelic effects and those manifestations of therapeutic interest. Considering the central role of the serotonin 5‐HT 2A receptor in the distinct effects of psychedelics in human psyche, neuropharmacology sits at the center of this debate and exploratory continuum. Here we discuss some of the most recent findings in human studies and contextualize them considering previous preclinical models studying phenomena related to synaptic plasticity. A special emphasis is placed on knowledge gaps, challenges, and limitations to evaluate the underpinnings of psychedelics’ potential antidepressant action. image