Microdosing psychedelics has no impact on cognitive function in naturalistic settings
Journal of Psychology & Clinical Psychiatry – August 01, 2023
Source: OpenAlex
Summary
Microdosing psychedelics does not objectively enhance neurocognitive performance, challenging popular belief. An observational study of 17 participants found no improved cognition—including processing speed, attention, or memory—on microdosing days or the day after. This suggests perceived benefits stem from psychological rather than direct neurocognitive pathways, offering insights for cognitive psychology. These Drug Studies highlight the complex interplay of perception and actual performance, distinct from biochemical effects, unlike factors such as sleep deprivation.
Abstract
Background and aim: Subjective and anecdotal accounts link ingestion of psychedelic microdoses, quantities small enough to retain perceptual clarity, to enhanced cognitive function and performance. In this study we review current evidence, test the link between domains of cognitive function and microdosing psychedelics and evaluate a remote testing approach for cognitive function. Methods: In an observational within-subjects design, we repeatedly assessed 17 participants during their microdosing regimen using the CNSVS neurocognitive battery in a naturalistic setting. Results: We found that neither the day of microdosing, nor the day after microdosing are significantly linked to enhanced or diminished performance on processing speed, sustained attention, inhibitory control, set shifting, working memory, visual memory and verbal memory. Conclusion: Microdosing psychedelics may act on psychological rather than neurocognitive pathways to induce a subjective feeling of performance enhancement. The use of remote cognitive batteries might benefit longitudinal cross-cultural studies by reducing participant burden