LSD-Like Panic From Risperidone in Post-LSD Visual Disorder
Journal of Clinical Psychopharmacology – June 01, 1996
Source: OpenAlex
Summary
Risperidone, an antipsychotic medication, may worsen symptoms in patients with hallucinogen-persisting perception disorder (HPPD). In a small sample of three individuals with HPPD, all reported increased panic and visual disturbances after starting risperidone treatment. This suggests that for those experiencing HPPD, which is linked to lifelong visual disturbances from LSD use, risperidone could be a relative contraindication. Understanding these interactions is crucial for effective treatment in psychology and psychiatry, particularly in managing panic disorders and conditions related to schizophrenia.
Abstract
Risperidone, a novel antipsychotic agent, is an antagonist of postsynaptic serotonin-2 and dopamine D2 receptors. In certain individuals, the hallucinogenic drug lysergic acid diethylamide (LSD) is associated with apparently lifelong continuous visual disturbances, characterized in DSM-IV as hallucinogen-persisting perception disorder (HPPD). Because the hallucinogenic mechanism of LSD is known to act in part at postsynaptic serotonin-2 receptors, it is noteworthy that three HPPD patients treated with risperidone reported an exacerbation of LSD-like panic and visual symptoms. We conclude that HPPD may be a relative contraindication for the use of risperidone.