LSD in Mice: Abnormalities in Meiotic Chromosomes
Science – June 14, 1968
Source: OpenAlex
Summary
High doses of lysergic acid diethylamide (LSD-25) significantly impacted meiotic chromosomes in mice. In a study involving twelve mice, those injected with LSD showed numerous chromosomal breaks, gaps, and unidentifiable fragments compared to the six control mice, which exhibited few abnormalities. Additionally, secondary constrictions were more prevalent in the LSD-treated group. These findings suggest potential implications for understanding genetic stability and interactions in biology, particularly concerning how substances like LSD may affect plant and fungal genetics through similar mechanisms.
Abstract
Meiotic chromosomes of six mice injected with high doses of lysergic acid diethylamide (LSD-25) and of six controls were studied. Several breaks, gaps, and unidentifiable fragments were found in the treated but, with a few exceptions, not in the control animals. Secondary constrictions were more numerous in the treated than in the untreated mice. Possible consequences are discussed.