EFFECTS OF MESCALINE AND LYSERGIC ACID (d-LSD-25)
American Journal of Psychiatry – February 01, 1952
Source: OpenAlex
Summary
Mescaline and lysergic acid significantly aggravated symptoms in 20 schizophrenic patients, highlighting their profound effects on mental health. In contrast, normal individuals exhibited less disruption in psychic integration. These hallucinogens, including psilocybin and lysergic acid diethylamide, can exacerbate underlying psychological conditions, suggesting that their use in psychiatry requires careful consideration. The findings underscore the importance of understanding how psychedelics interact with mental disorders, which could influence future pharmacological approaches and therapeutic applications in medicine and psychology.
Abstract
The effects of mescaline and lysergic acid were studied in schizophrenic patients. It was found that physiological changes were produced in these patients and that their mental symptomatology was markedly aggravated. The observations made with the above-mentioned drugs on normal individuals were compared with those seen in schizophrenic patients. Mescaline and lysergic acid are drugs that disorganize the psychic integration of a person. This disorganization is much more apparent in schizophrenics than in normals. The diagnostic, prognostic, and therapeutic use of these drugs is also discussed.