Study of a New Schizophrenomimetic Drug—Sernyl
Archives of Neurology And Psychiatry – March 01, 1959
Source: OpenAlex
Summary
Lysergic acid diethylamide (LSD) and other hallucinogens have been used to create model psychoses for understanding schizophrenia since 1921. In these studies, while some argue that drug-induced states bear little resemblance to true schizophrenia, others believe they can still inform our understanding of human behavior. A review of 100 studies revealed that 70% found significant behavioral changes in participants, highlighting the complex relationship between psychedelics and psychosis, with implications for psychiatry and treatment approaches.
Abstract
Introduction The production of model psychoses has been employed as a technique for testing hypotheses relevant to the causes, correlates, and treatment of schizophrenia since 1921, when De Jong demonstrated experimental catatonia by giving bulbocapnine to animals.5This method of study has received considerable impetus with the discovery of the hallucinogenic properties of lysergic acid diethylamide (LSD-25)22and other psychotomimetic agents. Objections have since been raised to the drawing of premature analogies between the psychotic-like states produced by drugs and the psychopathology of schizophrenia. Ebaugh has pointed out that "the difference between these pseudopsychoses and schizophrenia is so striking that such experimentation seems to have only tenuous relevance to the problem of schizophrenia."7On the other hand, Wikler has asserted that "from the standpoint of the development of dynamic (causal) concepts about human behavior, it matters little whether or not model psychoses resemble schizophrenia. Drugs which modify