Return of the lysergamides. Part VI: Analytical and behavioural characterization of 1‐cyclopropanoyl‐d‐lysergic acid diethylamide (1CP‐LSD)
Drug Testing and Analysis – March 16, 2020
Source: OpenAlex
Summary
1CP-LSD, a new lysergamide, shows potential as a psychoactive substance, acting similarly to LSD. In tests with C57BL/6 J mice, it induced a head-twitch response with an effective dose of 430 nmol/kg, comparable to 1P-LSD's 350 nmol/kg. Detailed analysis utilized techniques like mass spectrometry and chromatography, revealing that 1CP-LSD may degrade into LSD when incubated with human serum. This suggests it could function as a prodrug for LSD, highlighting the intricate chemistry behind psychedelics derived from plant and fungal interactions.
Abstract
Abstract Lysergic acid diethylamide (LSD) is a prototypical serotonergic psychedelic drug and the subject of many clinical investigations. In recent years, a range of lysergamides has emerged with the production of some being inspired by the existing scientific literature. Others, for example various 1‐acyl substituted lysergamides, did not exist before their appearance as research chemicals. 1‐Cylopropanoyl‐LSD (1CP‐LSD) has recently emerged as a new addition to the group of lysergamide‐based designer drugs and is believed to be psychoactive in humans. In this investigation, 1CP‐LSD was subjected to detailed analytical characterizations including various mass spectrometry (MS) platforms, gas and liquid chromatography, nuclear magnetic resonance spectroscopy, solid phase and GC condensed phase infrared spectroscopy. Analysis by GC–MS also revealed the detection of artificially induced degradation products. Incubation of 1CP‐LSD with human serum led to the formation of LSD, indicating that it may act as a prodrug for LSD in vivo, similar to other 1‐acyl substituted lysergamides. The analysis of blotters and pellets is also included. 1CP‐LSD also induces the head‐twitch response (HTR) in C57BL/6 J mice, indicating that it produces an LSD‐like behavioural profile. 1CP‐LSD induced the HTR with an ED 50 = 430.0 nmol/kg which was comparable to 1P‐LSD (ED 50 = 349.6 nmol/kg) investigated previously. Clinical studies are required to determine the potency and profile of the effects produced by 1CP‐LSD in humans.