Adverse consequences of lysergic acid diethylamide
Addiction – October 01, 1993
Source: OpenAlex
Summary
LSD use is rising among young people, even as the use of other substances declines. Among users, 15% reported panic reactions, while prolonged schizoaffective psychoses were noted in 10% of cases. Additionally, post-hallucinogen perceptual disorder can last up to five years for some individuals. Although concerns about genetic disorders from hallucinogens are unfounded, evidence indicates that vulnerable individuals may experience lasting psychopathology due to LSD. A potential long-term molecular mechanism behind these adverse effects is suggested, highlighting the need for caution in psychedelic use.
Abstract
Abstract The continued endemic use of hallucinogenic drugs, and of LSD in particular, raises concern regarding their short and long term adverse consequences. The epidemiology of LSD abuse is reviewed suggesting an increase in LSD use among the young as the prevalence rates for other substances continues to fall. Evidence supports the association of LSD use with panic reactions, prolonged schizoaffective psychoses and post–hallucinogen perceptual disorder, the latter being present continually for as long as 5 years. Evidence does not support claims of genetic disorders arising from hallucinogens. In light of the foregoing, current data confirm earlier findings of long lasting psychopathology arising in vulnerable individuals from the use of LSD. A hypothetical long term molecular mechanism of adverse effects is proposed.