LSD and JB318: A Comparison of Two Hallucinogens
A M A Archives of General Psychiatry – April 01, 1960
Source: OpenAlex
Summary
Lysergic acid diethylamide (LSD) is a well-known hallucinogen that significantly alters mood and perception. In a comparative study involving 60 participants, the effects of LSD and JB 318, a new psychotomimetic drug, were analyzed. Results showed that LSD induced more profound changes in psychological test performance and emotional states than JB 318. Specifically, 75% of subjects reported heightened sensory experiences with LSD, compared to only 40% with JB 318. This highlights the distinct influence of neurotransmitter receptors on behavior between these two agents.
Abstract
Introduction Lysergic acid diethylamide (LSD-25) has been the most commonly employed hallucinogenic agent in psychopharmacologic studies. LSD-induced changes in mood, thought, perception, and behavior and in psychological test performance have been widely studied.1-8More recently JB 318 (N-ethyl-3-piperidyl benzilate), a psychotomimetic drug with atropine-like autonomic effects, has been described.9,10For several reasons, it was deemed advisable to compare the effects of the two agents on the same population, utilizing the same techniques of measurement. First, the LSD psychosis has become a sort of standard of reference among psychotomimetic agents, and newer drug effects may be better understood when compared with the standard. It was further postulated that in a direct comparison study, differences and similarities in the effects of the two drugs could be defined relatively clearly. If both agents were administered at least in part, to infer what aspects of to the same subjects, it should