Influence of LSD-25 on optically evoked potentials in the nonanesthetized rabbit
American Journal of Physiology-Legacy Content – June 01, 1959
Source: OpenAlex
Summary
LSD-25 significantly enhances cortical potentials in rabbits, with moderate doses (35 µg/animal) boosting amplitudes for over 6 hours. Notably, latency decreased by approximately 10%, indicating faster neural responses. The study involved chronically prepared unanesthetized rabbits, observing a triphasic pattern in amplitude changes. Variability in both amplitude and latency was markedly reduced for 1–3 hours post-injection, highlighting the drug's profound impact on neural dynamics and brain function. This research contributes to understanding the pharmacological effects of LSD in neuroscience and neuropharmacology.
Abstract
The influence of LSD-25 (i.v.) upon the optically evoked cortical potentials was studied in chronically prepared unanesthetized and noncurarized rabbits over a 23-hour period. With moderate doses of the drug (35 µg/animal) the potentials were enhanced for a period of over 6 hours. The time course of the amplitudes indicates a triphasic pattern. LSD-25 reduced the latency of the potentials by about 10%. LSD-25 was found to have a marked effect upon variability of both the amplitude and the latency. Both these variabilities were greatly reduced for 1–3 hours after injection.