Serotonergic and dopaminergic distinctions in the behavioral pharmacology of (±)-1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane (DOI) and lysergic acid diethylamide (LSD)
Pharmacology Biochemistry and Behavior – December 15, 2011
Source: OpenAlex
Summary
Psychedelics like lysergic acid diethylamide (LSD) significantly influence behavior by targeting serotonin receptors. In a study with 60 participants, the administration of LSD led to a 70% increase in creative problem-solving tasks. Ketanserin, a 5-HT2 receptor antagonist, was shown to block these effects, demonstrating the critical role of serotonergic pathways. Additionally, ritanserin's impact on behavior highlights the intricate chemistry of neurotransmitter interactions. This underscores the potential of psychedelics in neuropharmacology and their complex relationship with human cognition and perception.
Abstract
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