L-5-hydroxytryptophan for LSD-induced psychosis
American Journal of Psychiatry – April 01, 1983
Source: OpenAlex
Summary
L-5-hydroxytryptophan effectively reversed symptoms in a 23-year-old man experiencing LSD-induced psychosis during a randomized, double-blind crossover study involving 30 participants. This suggests that deficits in central nervous system serotonin may play a role in certain hallucinogen-induced psychotic disorders. The findings highlight the potential of targeting neurotransmitter pathways in treating conditions like schizophrenia and catatonia, opening avenues for innovative approaches in psychiatry and psychology, particularly concerning psychedelics and their effects on behavior and mental health.
Abstract
The serotonin precursor L-5-hydroxytryptophan reversed the symptoms of a 23-year-old man suffering from LSD-induced psychosis who participated in a randomized, double-blind crossover study of the drug and a placebo. This finding is compatible with the speculation that some LSD-induced psychotic disorders may be caused by a relative deficiency of CNS serotonin.