Immunological Effects of Ayahuasca in Humans
Journal of Psychoactive Drugs – October 20, 2014
Source: OpenAlex
Summary
Ayahuasca, a traditional hallucinogen from the Amazon, is gaining global popularity, with use reported in the U.S., Europe, Asia, and Africa. While studies indicate good tolerability and safety, especially in ritual contexts, its immunological effects remain underexplored. With an increasing number of consumers—potentially thousands annually—understanding the risks associated with ayahuasca is crucial. This overview highlights the need for comprehensive data on its impact on human health, particularly as interest in psychedelics and traditional medicine continues to grow.
Abstract
Ayahuasca is a botanical hallucinogen traditionally used by indigenous groups of the northwest Amazon. In the last decade, the use of ayahuasca has spread from Brazil, Colombia, Ecuador, and Peru to the U.S., Europe, Asia, and Africa. Despite acute and long-term evidence of good tolerability and safety for ayahuasca administered in the laboratory or ritually consumed in religious contexts, little is known about the immunological impact of ayahuasca on humans. Since ayahuasca is used by an increasing number of consumers, and considering its therapeutic potential, more information is needed regarding ayahuasca potential risks. This article presents a brief overview of the available data regarding the immunological impact of ayahuasca in humans.