A Fatality Related to Two Novel Hallucinogenic Compounds: 4-Methoxyphencyclidine and 4-Hydroxy-N-methyl-N-ethyltryptamine
Journal of Analytical Toxicology – August 10, 2015
Source: OpenAlex
Summary
A man with a history of unusual behavior was found deceased, linked to the hallucinogen 4-methoxyphencyclidine (4-MeO-PCP). Toxicology revealed a peripheral blood concentration of 8.2 mg/L and a liver concentration of 120 mg/kg. Additionally, urine contained 140 mg/L of 4-MeO-PCP, while gastric contents had 280 mg. Other substances, including venlafaxine and hydroxyzine, were also present. The cause of death was determined to be acute mixed drug intoxication, classified as accidental. This case underscores the complexities in forensic toxicology and drug analysis.
Abstract
In this case report, we present an evaluation of postmortem concentration distribution of the hallucinogenic compound 4-methoxyphencyclidine (4-MeO-PCP) in a fatality principally attributed to this drug. Another hallucinogen, 4-hydroxy-N-methyl-N-ethyltryptamine was also detected, but was not quantitated. A man--who had a history of recent 'strange' behavior--was found deceased, on his bed, in his locked room. Toxicology testing, which initially screened positive for phencyclidine (PCP) by ELISA, subsequently detected and confirmed the two hallucinogens by gas chromatography-mass spectrometry. 4-MeO-PCP concentrations were then quantified by a specific secondary testing technique. The peripheral blood concentration was 8.2 mg/L compared with the central blood concentration of 14 mg/L. The liver concentration was 120 mg/kg, the vitreous was 5.1 mg/L, the urine was 140 mg/L and the gastric contents contained 280 mg. PCP was not detected, but therapeutic concentrations of venlafaxine, olanzapine, lorazepam and hydroxyzine were confirmed. The cause of death was certified due to acute mixed drug intoxication, and the manner of death was certified as accident.