EVALUATION OF THE THERAPEUTIC NEUROTOXIC EFFECTS OF THE USE OF AYAHUASCA BY DEPRESSIVE PATIENTS
Revista Contemporânea – September 05, 2023
Source: OpenAlex
Summary
Ayahuasca, a traditional tea made from Psychotria viridis and Banisteriopsis caapi, shows promise as a powerful antidepressant, with studies indicating reduced side effects compared to synthetic treatments. The leaves contain 0.1% to 0.6% DMT, which influences serotonin receptors in the brain. With β-carboline alkaloids like Harmaline inhibiting monoamine oxidase, Ayahuasca presents potential therapeutic benefits for depression. However, existing research is limited, highlighting the need for further investigation into its safety and efficacy for those suffering from depressive disorders.
Abstract
Ayahuasca is a tea used in original indigenous rituals with the aim of expanding the mind and consciousness. Some studies have pointed to Ayahuasca as a potent antidepressant with reduced side effects when compared to other conventional synthetic allopathic treatments. Over the years, tea has come to be known by both the popular community and the scientific community. The species used are Psychotria viridis and Banisteriopsis caapi, the leaves of Psychotria viridis have around 0.1% to 0.6% DMT. Psychotria viridis alkaloid, when ingested through Ayahuasca, exerts an agonist effect on 5-HT2A receptors in the brain, while Banisteriopsis caapi has a high concentration of β-carboline alkaloids such as Harmine, Harmaline and tetrahydroarmine, responsible for inhibiting monoamine oxidase (MAO), however, as well as the difficulties encountered in studies associated with the therapeutic benefits of the Cannabis sativa plant, especially in the face of traditional conservative movements, there are also few studies that indicate or position themselves on the neurotoxic and therapeutic potential, especially when used as possible treatments for the depression. Therefore, new natural therapies, including Ayahuasca, should be investigated for their toxic and therapeutic potential so that, as soon as safe parameters are identified, they can serve society, especially for depressive patients.