Presence and evolution of a new psychoactive tryptamines branch
European Psychiatry – March 01, 2016
Source: OpenAlex
Summary
The presence of 4-HO-DiPT is on the rise, with 4 samples identified in 2014 compared to none earlier. Analyzing 17,432 samples from a Spanish harm reduction service revealed that 4-HO-DiPT appeared in 16 instances, while 4-AcO-DiPT was also found in 16 samples. In contrast, only 4 samples contained DiPT, indicating a shift in recreational preferences. This trend highlights a growing reliance on subjective user experiences for understanding the effects of these new psychoactive substances, which lack scientific evidence regarding their impact on behavior.
Abstract
Introduction New psychoactive substances (NPS) are substances that have recently appeared on the market and are not under international control. NPS use is experiencing an unprecedented increase. DiPT, 4-HO-DiPT and 4-AcO-DiPT are new psychoactive tryptamines and their effects may differ from those of other psychoactive tryptamines. Objective To explore the presence of DiPT, 4-HO-DiPT and 4-AcO-DiPT from samples delivered to and analyzed by Spanish harm reduction service Energy Control. Materials and methods All samples analyzed from 2009 to 2014 delivered as DiPT, 4-HO-DiPT and 4-AcO-DPT or containing these substances. Analysis was performed by gas chromatography–mass spectrometry. Results From 17,432 samples, 4-HO-DiPT was found in 16, delivered as 4-HO-DiPT (6); 4-AcO-DiPT (7); DiPT (1); 4-AcO-DMT (1) and cocaine (1). 4-AcO-DiPT was found in 16, delivered as 4-AcO-DiPT (12); 5-MeO-DMT (1); 5-MeO-DiPT (1); 4-AcO-DMT (1) and cocaine (1). Only 4 samples contained DiPT, all presented as DiPT. Nine samples contained both 4-AcO-DiPT and 4-HO-DiPT. During the years of study, 4-HO-DiPT deliverance was increasing (4 samples in 2014) while deliverance of 4-AcO-DiPT and DiPT was decreasing (1 sample in 2014). Conclusions Increasing 4-HO-DiPT presence could translate a progressive replacement of 4-AcO-DiPT and DiPT recreational use. Clinical relevance comes from its growing use and the absence of scientific evidence on humans, therefore relying on users subjective experience to predict the effects. Disclosure of interest The authors declare that they have no competing interest.