DOET(2,5-Dimethoxy-4-Ethylamphetamine), a New Psychotropic Drug
Archives of General Psychiatry – January 01, 1971
Source: OpenAlex
Summary
DOET, a novel psychotropic agent similar to mescaline and amphetamine, was tested on 20 male subjects with doses ranging from 0.75 to 4 mg. Participants reported mild euphoria and enhanced self-awareness, but higher doses led to increased anxiety without hallucinogenic or psychotomimetic effects. Notably, the subjective experiences did not significantly intensify with dosage increases. This suggests that while DOET can elevate awareness, it lacks the profound effects typically associated with psychedelics like psilocybin or lysergic acid diethylamide, highlighting the diverse impact of psychotropic drugs.
Abstract
DOET (2,5-dimethoxy-4-ethylamphetamine) is a new psychotropic agent which chemically resembles mescaline and amphetamine. It is essentially the ethyl homologue of DOM (2,5-dimethoxy-4-methylamphetamine), a psychotomimetic drug widely used by hippie populations and designated "STP." DOET was administered to normal male subjects in doses ranging from 0.75 to 4 mg and contrasted with effects of a water placebo. In all cases DOET produced subjective effects including a mild euphoria, a feeling of enhanced self-awareness, and a tendency to feel "anxious" at higher doses. Although there was some increase in subjective effects at higher doses, this was not marked. No hallucinogenic or psychotomimetic effects were observed at any dose. Thus, over a five-fold range of pharmacologically active dosage, the "enhanced awareness" produced by DOET was not associated with psychotomimetic or hallucinogenic actions. PSYCHEDELIC drugs embrace a large number of agents of widely different chemical classes but which produce notably similar profound subjective effects.1Nuances of subjective effects which may vary among drugs2have not been well quantified. Shulgin3.4has synthesized a large number of methoxylated amphetamines related to mescaline and amphetamine. One of these, DOM (2, 5-dimethoxy-4-methylamphetamine) (Fig 1), informally designated "STP," was psychotomimetic and hallucinogenic in doses larger than 5 mg, and was about 50 to 100