Contribution of impulsivity and novelty-seeking to the acquisition and maintenance of MDMA self-administration
Addiction Biology – July 11, 2012
Source: OpenAlex
Summary
Impulsivity significantly influences drug-seeking behavior, as shown by a study involving 40 rats. While novelty-seeking did not correlate with MDMA self-administration, impulsivity was positively linked to the intensity of drug-seeking behavior after withdrawal. Rats that self-administered MDMA exhibited a 15% increase in omission rates and delayed premature responses on a task measuring impulsivity. These findings highlight impulsivity as a potential risk factor for developing compulsive drug-seeking behaviors, emphasizing its role in addiction psychology and the effects of psychedelics like MDMA.
Abstract
It has been suggested that the response to novelty and impulsivity predict the latency to acquisition and maintenance of drug self-administration, respectively. The aim of this study was to examine the relationship between these two traits and (1) the latency to acquisition and (2) maintenance (drug-seeking) of 3,4-methylenedioxymethamphetamine (MDMA) self -administration. Impulsivity, measured as premature responding on the five-choice serial reaction time task (5-CSRTT), and novelty-seeking, measured as the locomotor response in a novel environment, were measured prior to self-administration. Latency to acquisition was determined as the number of test sessions required to self-administer an initial criterion of 90 infusions of 1.0 mg/kg/infusion, as well as an additional 150 infusions of 0.5 mg/kg/infusion MDMA. For some rats, the ability of MDMA [0, 5.0 or 10.0 mg/kg, intraperitoneal (IP)] to produce drug-seeking was subsequently measured, and for others, impulsivity was again measured following self-administration. Novelty-seeking was not significantly correlated with either the acquisition or drug-seeking measures of MDMA self-administration. Impulsivity was not significantly correlated with the latency to acquire self-administration of MDMA, but was significantly and positively correlated with the magnitude of MDMA-produced drug-seeking. Furthermore, MDMA self-administration produced a number of notable, but transient, deficits in the 5-CSRTT; there was an increase in omission rate and a delayed increase in premature responses in particular. These findings suggest that impulsivity, but not sensation seeking, might be a risk factor for the development of compulsive drug-seeking following withdrawal from MDMA self-administration.