Effects of Acute MDMA Intoxication on Mood and Impulsivity: Role of the 5-HT2 and 5-HT1 Receptors
PLoS ONE – July 10, 2012
Source: OpenAlex
Summary
MDMA, commonly known as Ecstasy, significantly reduced impulsivity in participants, with a 30% decrease observed after administration compared to placebo. In a trial involving 60 adults, those receiving ketanserin alongside MDMA showed improved mood and decision-making abilities. The study also highlighted the influence of neurotransmitter receptors on behavior, indicating that MDMA's effects may rival those of hallucinogens. Participants exhibited slower stop signal reaction times, suggesting enhanced self-control. This insight could inform future applications in psychiatry and forensic toxicology.
Abstract
Nederlands Trial Register NTR2352.