Lasting Neuropsychiatric Sequelae of (??)Methylenedioxymethamphetamine (???Ecstasy???) in Recreational Users
Journal of Clinical Psychopharmacology – October 01, 1991
Source: OpenAlex
Summary
Prolonged neuropsychiatric syndromes were observed in two individuals after ingesting large doses of MDMA, a popular recreational amphetamine analog. These cases highlight that MDMA, while often associated with euphoric effects, may lead to significant and lasting adverse consequences, particularly for those already vulnerable. Given that MDMA is known to be neurotoxic to serotonin neurons in animal studies, these findings raise concerns about its impact on human health, suggesting potential risks of serious psychological effects following high doses.
Abstract
Two persons are described who demonstrated prolonged neuropsychiatric syndromes after the ingestion of large doses of (+-)-3,4-methylenedioxymethamphetamine (MDMA), a recreationally used amphetamine analog. These cases suggest that MDMA, known to be neurotoxic to serotonin neurons in several experimental animals, may also produce untoward effects in humans. In addition, they provide evidence that ingestion of large doses of MDMA can produce lasting adverse functional consequences in vulnerable persons.