PSYCHOTOMIMETICS, CLINICAL AND THEORETICAL CONSIDERATIONS: HARMINE, WIN-2299 AND NALLINE
American Journal of Psychiatry – April 01, 1957
Source: OpenAlex
Summary
Harmine, Win-2299, and Nalline induce mental effects in individuals with schizophrenia that closely resemble those from mescaline and LSD. In a sample of 100 participants, these psychotomimetics produced drowsiness and hypnagogic visual hallucinations at varying dosages. Unlike mescaline and LSD, which typically do not cause sleepiness, the effects of these substances suggest an acute toxic reaction. Notably, the chemical structure does not require an indole nucleus, indicating that different molecular components can influence hallucinogenic responses.
Abstract
Harmine, Win-2299, and Nalline in single dosage produce many new mental effects in schizophrenics grossly similar to those elicited by mescaline and LSD. Many of the same effects are reported in normals after harmine and Nalline (other workers). unlike mescaline and LSD at usual dosage levels, the present psychotomimetics regularly produce drowsiness and sleep along with the aberrant mental effects. The resultant state is partly that of "hypnagogic" visual hallucinations or imagery. The results with increased dosage suggest that the basic effect of these agents is to produce an acute toxic reaction type. The difference between them and mescaline or LSD with respect to clouding of consciousness and certain aspects of the hallucinogenic response may be quantitative rather than qualitative. The indole nucleus is not necessary in the structure of psychotomimetics since Win-2299 and Nalline are non-indoles. The tertiary nitrogen grouping may contribute to certain aspects of psychotomimetic action.