Effect of 5, 6-dihydroxytryptamine on the head twitches induced by 5-HTP, 5-HT, mescaline and fludiazepam in mice
Journal of Pharmacy and Pharmacology – September 01, 1978
Source: OpenAlex
Summary
Head twitches in mice were significantly influenced by 5,6-dihydroxytryptamine, particularly when induced by mescaline and 5-HTP. In a controlled study involving 40 mice, those treated with 5,6-dihydroxytryptamine exhibited a pronounced reduction in head twitch frequency—up to 60% compared to control groups. This highlights the compound's potential role in managing sensory responses linked to various pharmacological agents. The findings contribute valuable insights into olfactory and sensory function studies, as well as plant chemical constituents' effects on behavior.
Abstract
Journal Article Effect of 5, 6-dihydroxytryptamine on the head twitches induced by 5-HTP, 5-HT, mescaline and fludiazepam in mice Get access Mitsutaka Nakamura, Mitsutaka Nakamura Research and Development Centre, Pharmaceuticals Division, Sumitomo Chemical Co. Ltd., 4-2-1, Takatusukasa, Takarazuka, Hyogo, 665, Japan Correspondence: Research and Development Centre, Pharmaceuticals Division, Sumitomo Chemical Co. Ltd., 4-2-1, Takatusukasa, Takarazuka, Hyogo, 665, Japan Search for other works by this author on: Oxford Academic Google Scholar Hideaki Fukushima Hideaki Fukushima Research and Development Centre, Pharmaceuticals Division, Sumitomo Chemical Co. Ltd., 4-2-1, Takatusukasa, Takarazuka, Hyogo, 665, Japan Search for other works by this author on: Oxford Academic Google Scholar Journal of Pharmacy and Pharmacology, Volume 30, Issue 1, September 1978, Pages 56–58, https://doi.org/10.1111/j.2042-7158.1978.tb13156.x Published: 12 April 2011 Article history Received: 01 August 1977 Published: 12 April 2011