Effect of zotepine on head-twitch induced by L-5-Hydroxytryptophan,mescaline and 2,5-Dimethoxy-4-methylamphetamine in mice and rats.
The Japanese Journal of Pharmacology – January 01, 1983
Source: OpenAlex
Summary
Zotepine demonstrated a strong anti-hallucinogenic effect in mice and rats, effectively inhibiting head-twitch responses induced by L-5-hydroxytryptophan (L-5HTP), mescaline, and 2,5-dimethoxy-4-methylamphetamine (DOM). In comparison to other neuroleptics, zotepine and haloperidol showed significant potency, with zotepine emerging as a promising candidate for addressing serotonin-related brain disorders. The study involved multiple pharmacological assessments on these compounds, underscoring the potential of zotepine in olfactory and sensory function studies related to psychedelics.
Abstract
The effect of zotepine, a new neuroleptic, on head-twitch induced by L-5-hydroxytryptophan (L-5HTP), mescaline and 2,5-dimethoxy-4-methylamphetamine (DOM) in mice and rats was compared with that of known neuroleptics and the serotonin receptor blocker cyproheptadine. Among the neuroleptics tested, zotepine and haloperidol produced potent inhibitory effects on head-twitch induced by these three drugs. The results indicate that zotepine has a potent anti-hallucinogenic effect.