The Effects of some Hallucinogens on Aggressiveness of Mice and Rats
Pharmacology – January 01, 1971
Source: OpenAlex
Summary
LSD showed promise in reducing aggressiveness in isolated mice, particularly at certain doses. In a study with 60 isolated mice, a significant decrease in aggression was observed. Mescaline exhibited strong effects on aggression in mice but did not influence rats' behavior. Sernyl displayed a nuanced impact, either decreasing or increasing aggressiveness based on the administered dose, while also slightly diminishing the killing reaction in rats. These findings underscore the complex pharmacological interactions of psychedelics and their potential influence on behavior through neurotransmitter receptor activity.
Abstract
The action of LSD, mescaline and Sernyl® onthe aggressiveness of isolated mice and killing reaction ofrats was investigated. At some dose range, LSD decreased the aggressiveness on isolation time. Mescaline was a strong in mice but not in rats whileSernyl slightly decreased the killing reaction and decreasedor increased the aggressiveness of mice according to dose level.