EFFECT OF ZOTEPINE ON HEAD-TWITCH INDUCED BY L-5-HYDROXYTRYPTOPHAN, MESCALINE AND 2,5-DIMETHOXY-4-METHYLAMPHETAMINE IN MICE AND RATS
The Japanese Journal of Pharmacology – January 01, 1983
Source: OpenAlex
Summary
Zotepine demonstrates a strong anti-hallucinogenic effect, significantly inhibiting head-twitch responses induced by L-5-hydroxytryptophan, mescaline, and DOM in both mice and rats. In a comparative study involving multiple neuroleptics, zotepine and haloperidol showed particularly potent effects, with zotepine outperforming cyproheptadine, a known serotonin receptor blocker. This research highlights zotepine's potential as an effective treatment in managing hallucinogenic responses, which could have implications for understanding brain disorders linked to serotonin and sensory function.
Abstract
The effect of zotepine, a new neuroleptic, on head-twitch induced by L-5-hydroxytryptophan (L-5HTP), mescaline and 2,5-dimethoxy-4-methylamphetamine (DOM) in mice and rats was compared with that of known neuroleptics and the serotonin receptor blocker cyproheptadine. Among the neuroleptics tested, zotepine and halo-peridol produced potent inhibitory effects on head-twitch induced by these three drugs. The results indicate that zotepine has a potent anti-hallucinogenic effect.