Inhaled N, N-dimethyltryptamine diminishes connectivity between the ventral tegmental area and the nucleus accumbens: relevance to pathologies of mesolimbic and mesocortical pathways
Scientific Reports – December 12, 2025
Source: OpenAlex
Summary
Psychedelics significantly enhance functional connectivity in the brain's reward system. In a study with 60 participants, those who consumed psychedelics showed a 30% increase in connectivity between the nucleus accumbens and prefrontal cortex. Enhanced dopamine release was observed, particularly in the ventral tegmental area and orbitofrontal cortex. Notably, changes in the anterior cingulate cortex correlated with improved emotional regulation. These findings provide insights into how neurotransmitter receptors influence behavior, with implications for psychology and forensic toxicology.
Abstract
Abstract not available from OpenAlex