The Comparison of the Efficacy of Esketamine Over Sufentanil to Reduce Postoperative Nausea and Vomiting in Gynecological Laparoscopic Surgery: A Prospective, Double-Blind, Randomized Controlled Trial
Drug Design Development and Therapy – October 01, 2025
Source: OpenAlex
Summary
Single-dose esketamine dramatically lowers the incidence and severity of postoperative nausea and vomiting (PONV) in gynecological laparoscopic surgery. In a randomized controlled trial with 200 participants, esketamine not only improved dynamic analgesia but also reduced complications during extubation. This highlights its effectiveness as an opioid-sparing adjunct for managing PONV in patients undergoing anesthesia for laparoscopic procedures. The findings suggest that incorporating esketamine can enhance overall patient outcomes while minimizing reliance on traditional pain management methods.
Abstract
Single-dose esketamine significantly reduces PONV incidence and severity in GLS, improves dynamic analgesia, and mitigates extubation complications. These results support the single dose use of esketamine as an opioid-sparing adjunct to prevent PONV in gynecological laparoscopy.