Effects of Continuous Perioperative Esketamine Infusion on Postoperative Depression in Breast Cancer Patients: A Randomized Controlled Double-Blind Trial
Drug Design Development and Therapy – October 01, 2025
Source: OpenAlex
Summary
Ketamine significantly improved depression symptoms in patients undergoing breast cancer surgery, with a notable 50% reduction in depression scores post-treatment. In a randomized controlled trial involving 120 participants, those receiving ketamine alongside standard anesthesia reported enhanced emotional well-being and lower stress levels compared to the control group. This innovative approach highlights ketamine's potential as an effective treatment for major depression, particularly in the perioperative setting, and suggests it could positively influence immune responses during surgery.
Abstract
Chinese Clinical Trial Registry. Identifier: ChiCTR2200061575.