Appearance of necrotizing sialometaplasia temporarily associated with MDMA consumption
Journal of Clinical and Experimental Dentistry – January 01, 2026
Source: OpenAlex
Summary
A 24-year-old woman developed necrotizing sialometaplasia after using MDMA, a stimulant known for its psychoactive effects. Symptoms appeared shortly after licking MDMA powder onto her oral mucosa. Following symptomatic treatment, she experienced complete healing of the lesions. This case highlights a previously unrecognized link between MDMA consumption and necrotizing sialometaplasia, suggesting potential implications for dermatology, pathology, and forensic toxicology. Understanding this relationship could inform future medical approaches to diagnosis and treatment in similar cases.
Abstract
We reported the case of a 24-year-old woman presented with necrotizing sialometaplasia associated temporally with 3,4-methylenedioxymethamphetamine (MDMA) use.The patient reported having consumed MDMA powder licked onto the oral mucosa days before the appearance of the lesions.Symptomatic treatment of the presenting lesions was carried out, with a follow-up that demonstrated complete healing of the lesions.The clinical case is presented and possible pathophysiological mechanisms that may justify the relationship between MDMA and necrotizing sialometaplasia are discussed.This report describes the relationship between a new, previously undescribed aetiological factor related to necrotizing sialometaplasia.