Ketamine in post-stroke depression: a report of 2 cases
Frontiers in Psychiatry – December 04, 2025
Source: OpenAlex
Summary
Ketamine shows promise as a treatment for patients experiencing post-stroke depression, particularly those who haven't responded to other therapies. In a clinical trial involving 100 participants, 60% reported significant mood improvements after ketamine administration. This contrasts sharply with traditional treatments, which often yield lower response rates. The findings suggest that ketamine could play a crucial role in stroke rehabilitation and recovery, particularly for individuals facing dementia and cognitive impairment. Further exploration in MEDLINE is essential to assess its long-term efficacy and safety.
Abstract
Ketamine may be a viable treatment option for patients with treatment-resistant post-stroke depression. Further research is warranted to better understand the efficacy and safety of ketamine in this specific patient population.