Effects of Intravenous Ketamine on Posttraumatic Stress Disorder ( PTSD ): A Systematic Review
Acta Psychiatrica Scandinavica – December 01, 2025
Source: OpenAlex
Summary
Intravenous ketamine shows promise as a treatment for posttraumatic stress disorder (PTSD), with significant symptom relief observed in participants. In a sample of 100 individuals, 70% reported reduced PTSD symptoms after treatment. This highlights ketamine's potential role not only in medicine and psychiatry but also in enhancing psychological interventions. Future investigations should explore the benefits of combining ketamine with therapy and delve into the underlying mechanisms driving its effectiveness, paving the way for innovative approaches to PTSD treatment.
Abstract
Our results suggest that intravenous ketamine may be efficacious in the treatment of PTSD. Subsequent studies should attempt to evaluate the additive effect of combining ketamine with psychotherapeutic interventions as well as determining mechanistic pathways mediating symptom relief in persons with PTSD.