Safety, effectiveness and tolerability of sublingual ketamine in depression and anxiety: A retrospective study of off-label, at-home use
K. Hassan, W. Struthers, Aditya Sankarabhotla, Patrick Davis
Frontiers in Psychiatry September 28, 2022 DOI: 10.3389/fpsyt.2022.992624 via Semantic Scholar
Summary
Sublingual rapid-dissolve ketamine tablets, self-administered at home, safely reduce symptoms of depression and anxiety in people with treatment-resistant depression. After three doses, nearly half of patients showed meaningful improvement on standard depression and anxiety questionnaires. Improvement rates were higher among those who completed a full course of six doses. This delivery method offers a practical alternative to intravenous ketamine.
Study at a glance
| Characteristics | Observational cohort Peer reviewed |
|---|---|
| Population | Patients with treatment-resistant depression |
| Keywords | Medicine |
| Citations | 25 |
| Key finding | Sublingual ketamine tablets significantly reduce depression and anxiety scores in treatment-resistant patients, with greater improvement after six doses than after three. |
Abstract
Intravenous and intranasal ketamine have been shown to be effective therapeutic options in patients suffering from treatment-resistant depression (TRD). The use of sublingual (SL), rapid dissolve ketamine tablets (RDT) offers a novel approach for delivery for mental health indications. This study assessed the effectiveness and safety of self-administration of off-label, SL, rapid dissolve ketamine tablets (RDT) at-home for depression and anxiety. Intake scores on the Generalized Anxiety Disorder Screener (GAD-7) and Patient Health Questionnaire (PHQ-9) were compared to scores after treatments of three doses of ketamine RDT, and after six doses of ketamine RDT. After three doses of SL ketamine, 47.6% of patients showed a significant decrease in PHQ-9 scores, and 47.6% of patients showed a significant reduction in GAD-7 scores. Reduction rates were higher in those patients who completed a clinically recommended six doses of RDT ketamine. This study demonstrates that SL ketamine is a novel, safe, and effective treatment for TRD and treatment-resistant anxiety. SL ketamine offers an alternative therapeutic approach to IV ketamine when treating those with TRD.