Safety, effectiveness and tolerability of sublingual ketamine in depression and anxiety: A retrospective study of off-label, at-home use
Frontiers in Psychiatry September 28, 2022 K. Hassan, W. Struthers, Aditya Sankarabhotla et al. 25 citations
Sublingual rapid-dissolve ketamine tablets, self-administered at home, safely reduce symptoms of depression and anxiety in people with treatment-resistant depression. After three doses, nearly half of patients showed meaningful improvement on standard depression and anxiety questionnaires. Improvement rates were higher among those who completed a full course of six doses. This delivery method offers a practical alternative to intravenous ketamine.