One-Year Outcomes Following Intravenous Ketamine Plus Digital Training Among Patients with Treatment-Resistant Depression
R. Price, M. Wallace, S. Mathew, R. Howland
JAMA Network Open May 1, 2023 DOI: 10.1001/jamanetworkopen.2023.12434 via Semantic Scholar
Summary
Automated self-association training may extend the antidepressant effect of a single ketamine infusion beyond one month in people with treatment-resistant depression. This secondary analysis of a randomized clinical trial tested whether a computerized task designed to strengthen positive self-associations could prolong the benefits of ketamine. The results suggest that combining ketamine with this training could help maintain mood improvement for a longer period than ketamine alone.
Study at a glance
| Characteristics | Secondary analysis of a randomized clinical trial Peer reviewed |
|---|---|
| Population | Patients with treatment-resistant depression |
| Keywords | Medicine Psychology |
| Citations | 9 |
| Key finding | Automated self-association training may prolong the antidepressant effect of a single ketamine infusion beyond one month in patients with treatment-resistant depression. |
Abstract
This secondary analysis of a randomized clinical trial examines whether automated self-association training can prolong the antidepressant effect of a single infusion of ketamine beyond 1 month in patients with treatment-resistant depression.