In reply – on the toxicity of ibogaine

Summary

Ibogaine, iboga extracts, and the root bark of iboga lack a clear therapeutic dose margin, meaning the difference between an effective dose and a toxic dose is not well defined. The authors agree with this observation and discuss its implications for safe use.

Study at a glance

Abstract

We concur with the observation of the authors that ibogaine does not seem to have a clear therapeutic dose margin, nor does iboga extracts or the root bark of iboga. However, what they consider to ...