Clinical toxicology
January 1, 1975
John Klock, Udo Boerner, Charles E. Becker
78 citations
Eight people who snorted large amounts of pure LSD powder were seen within 15 minutes. They vomited, collapsed, and showed signs of overactive sympathetic nervous system, high body temperature, coma, and stopped breathing. Several had mild generalized bleeding, and all had evidence of platelet dysfunction. LSD concentrations in blood ranged from 2.1 to 26 ng/ml and in stomach contents from 1000 to 7000 mcg/100 ml. With supportive care, all patients recovered. Massive LSD overdose in humans is life-threatening and produces striking and distinctive symptoms.
Clinical toxicology
January 1, 1977
Kenneth Blum, San Ford L. Futterman, Paul Pascarosa
34 citations
Alcohol and opiate abuse among both Indian and non-Indian individuals became asymptomatic under Native American guidance and through participation in the peyote ritual. Biochemical alkaloids in the peyote cactus, not just mescaline, are pharmacologically similar to neuroamine-derived alkaloids found in the brain during alcohol intoxication. Evidence suggests possible common features of alcohol and opiate dependence, leading to speculation that a common mode of treatment may reside in plants rich in isoquinoline alkaloids.
Clinical toxicology
May 31, 2016
L. Yip, Jou‐fang Deng
3 citations
No Summary
Clinical toxicology
May 31, 2016
T. Brunt, Ruud P. W. Litjens
Ibogaine, iboga extracts, and the root bark of iboga lack a clear therapeutic dose margin, meaning the difference between an effective dose and a toxic dose is not well defined. The authors agree with this observation and discuss its implications for safe use.