A rat model of phencyclidine psychosis.
S Ogawa, S Okuyama, H Araki, A Nakazato, S Otomo
Life sciences January 1, 1994 DOI: 10.1016/0024-3205(94)00326-2 via PubMed
Summary
AI-generated from the abstractRats given low doses of phencyclidine (PCP) showed impaired performance in water maze and diving tasks: their swimming latencies shortened gradually while diving latencies increased, whereas control rats performed well. No stereotyped behavior or hyperlocomotion was observed. The authors propose that this animal model, using lower PCP doses, may be useful for studying schizophrenia.
Study at a glance
| Characteristics | Animal model Peer reviewed |
|---|---|
| Population | Rats |
| Intervention | Phencyclidine (PCP) |
| Dose | lower doses |
| Key finding | Low doses of PCP impaired rats' performance in water maze and diving tasks without producing stereotyped behavior or hyperlocomotion. |
Abstract
Phencyclidine (PCP)-induced behavior in rats was investigated in water maze and diving behavior tasks. The swimming and diving latencies of PCP-treated groups placed in a water maze apparatus were gradually shortened, and prolonged, respectively, while rats in a control group performed well. In all rats, stereotyped behavior and hyperlocomotion were absent. We propose that this animal model induced by lower doses of PCP may be useful for further studies to research schizophrenia.