Research
Calcium channels in anesthesia management: A molecular and clinical review.
Molecular pain – January 01, 2025
Summary
Calcium channels act as molecular gatekeepers in our nervous system, controlling how we respond to anesthesia. These channels regulate consciousness and pain perception by managing calcium flow in nerve cells. Recent advances show that anesthetic mechanisms work by precisely targeting these channels, leading to more effective pain control. Understanding calcium channelopathies helps doctors personalize anesthesia for better patient safety and outcomes.
Abstract
Calcium channels play an essential role in the molecular and physiological mechanisms underlying anesthesia by mediating intracellular calcium ion ...
Multidimensional Analysis of Twin Sets During an Intensive Week-Long Meditation Retreat: A Pilot Study.
Mindfulness – January 01, 2025
Summary
Twins exhibited synchronized brain activity during meditation, even when separated. This pilot explored how mind-body practices influence individuals. Using quantitative electroencephalography (qEEG), gene expression, and metabolomics, positive shifts in brain activity, gene expression, and metabolites were observed. Twin pairs showed remarkable alignment, underscoring meditation's profound benefits.
Abstract
Meditation has long been known to promote health. We utilized a multidisciplinary approach to investigate the impact of mind-body interventions on ...
KETAMIR-2, a new molecular entity and novel ketamine analog.
Frontiers in pharmacology – January 01, 2025
Summary
Remarkably, a new ketamine analog, ketamir-2, avoids the psychomotor agitation seen with traditional ketamine. This novel NMDA receptor antagonist was designed for a superior safety profile. Unlike ketamine, ketamir-2 did not induce hyperlocomotion in tests. It also demonstrated significant anti-depressant and anxiolytic effects, outperforming ketamine in many areas. This suggests a promising, safer therapeutic option.
Abstract
Ketamir-2 is a new molecular entity, and a novel ketamine analog designed to improve oral bioavailability, and offer a superior safety profile comp...
Abuse liability for esketamine in a cohort of patients undergoing an acute treatment course to manage treatment-resistant depression: a secondary analysis of an observational study in real-world clinical practicee.
Therapeutic advances in drug safety – January 01, 2025
Summary
Many worry about addiction with new depression treatments, especially those related to ketamine abuse. However, a study using real-world clinical data on 23 patients with major depressive disorder found promising results. This psychopharmacology research assessed esketamine's abuse liability during an acute treatment course. Patients reported neutral liking and no cravings, which did not increase over eight sessions. This suggests a positive antidepressant effect and treatment response without heightened risk, offering hope for those with severe depression, including suicidal ideation, by showing low abuse potential.
Abstract
Intranasal (IN) esketamine has become an effective and well-tolerated therapeutic option for the management of treatment-resistant depression withi...
A Multi-Site, Randomized, Parallel-Group, Controlled Trial of Virtually-Delivered Sahaj Samadhi Meditation for the Management of Moderate Depressive Symptoms in Chronic Pain.
Journal of pain research – January 01, 2025
Summary
A new clinical trial suggests a virtual meditation program could offer significant relief for those managing both chronic pain and depressive disorder. This mind-body therapy was tested against a control program. While direct group comparisons were not significant, participants practicing the meditation showed substantial, clinically meaningful improvements in their depressive symptoms over 24 weeks. This indicates meditation is a promising approach for these co-occurring conditions.
Abstract
Chronic pain (CP) often co-occurs with depression, but promising scalable interventions have been under-investigated. We assessed the effectiveness...
Development of a diagnostic variable number tandem repeat marker and dual TaqMan genotyping assay to distinguish Lophophora species.
International journal of legal medicine – January 01, 2025
Summary
Scientists have developed a groundbreaking DNA test to distinguish between two similar cacti species - one containing mescaline and another that doesn't. The new method uses variable number tandem repeats and TaqMan genotyping to accurately identify Lophophora williamsii from Lophophora diffusa, helping law enforcement better regulate controlled substances.
Abstract
The Lophophora genus of the Cactaceae family includes Lophophora diffusa and Lophophora williamsii, which has traditionally been used as a natural ...
My Bad, You Got This: witnessing, therapist attitude and the synergy between psychedelics and inner healing intelligence in the treatment of trauma.
Frontiers in psychology – January 01, 2025
Summary
MDMA-assisted therapy shows remarkable promise in trauma treatment by tapping into our natural capacity to heal. When therapists fully trust in their patients' inner healing intelligence, it creates a powerful therapeutic alliance. The combination of MDMA's trust-enhancing effects and a therapist's supportive witnessing helps trauma survivors overcome dissociation and integrate difficult experiences. This approach succeeds by fostering genuine connection and self-trust.
Abstract
The MAPS (Multidisciplinary Association for Psychedelic Studies) sponsored MDMA-assisted therapy protocol has had greater success in treating traum...
From Isolation to Social (and Psychedelic) Integration: A Sociology of Collective Effervescence and Therapeutic Community in Psychedelic-Assisted Therapy.
Sociol Health Illn – January 01, 2025
Summary
Remarkably, feeling connected can significantly amplify healing. This work explores how psychedelic therapy, when combined with strong social bonds and shared transformative experiences, helps individuals move beyond isolation. By fostering a supportive therapeutic community, this approach promotes deep social integration. The findings underscore the profound power of human connection in achieving positive mental well-being.
Abstract
From Isolation to Social (and Psychedelic) Integration: A Sociology of Collective Effervescence and Therapeutic Community in Psychedelic-Assisted T...
Thalamus and consciousness: a systematic review on thalamic nuclei associated with consciousness.
Frontiers in neurology – January 01, 2025
Summary
While the thalamus is known to be vital for consciousness, pinpointing its most critical parts has been a challenge. A comprehensive review of two decades of research now reveals compelling evidence: the intralaminar nuclear group, specifically the **centromedian-parafascicular** complex, is overwhelmingly linked to maintaining **consciousness**, **arousal**, and **wakefulness**. This region of the **thalamus** appears to be a central hub. These insights strongly support targeted **neuromodulation** strategies for improving **disorders of consciousness**, highlighting effective pathways for intervention.
Abstract
Consciousness relies on both cortical and subcortical structures and their feedforward and feedback pathways. Within this framework, the thalamus r...
The Effect of Minimal-Dose S-Ketamine Administration Post-Surgery on Opioids Consumption and Functional Rehabilitation Exercises in Patients Undergoing Minimally Invasive Radical Resection of Esophageal Cancer.
Therapeutics and clinical risk management – January 01, 2025
Summary
For patients recovering from esophageal cancer surgery, a minimal dose of S-ketamine remarkably reduced opioid consumption by 40%. This finding emerged from a comparison where patients received either S-ketamine or a placebo for postoperative analgesia. Those given S-ketamine not only used significantly less pain medication but also showed superior functional recovery. This approach offers a promising way to enhance patient rehabilitation.
Abstract
To examine the impact of minimal-dose S-ketamine on postoperative analgesia in patients undergoing minimally invasive radical resection for esophag...
Quantitative LC-QToF-MS Analysis of Mycochemicals in Amanita muscaria, Psilocybe spp. (Agaricomycetes), and Consumer Products.
International journal of medicinal mushrooms – January 01, 2025
Summary
Recent analysis of psychedelic mushroom products reveals significant quality control issues in the expanding market. Scientists developed a precise testing method to measure key compounds in both Amanita muscaria and Psilocybe mushroom products. Testing of 27 commercial items found concerning discrepancies - some gummies lacked expected compounds, while others contained substances not listed on labels.
Abstract
The psychedelic mushroom market has expanded rapidly due to changing regulations and increasing consumer demand. Product diversity now extends beyo...
Emerging Risks of Amanita Muscaria: Case Reports on Increasing Consumption and Health Risks.
Acta medica Lituanica – January 01, 2025
Summary
Four people recently hospitalized for consuming *Amanita muscaria* were all discharged in stable condition, revealing a growing trend. This review highlights increased recreational use of these psychoactive mushrooms, driven by compounds like muscimol and its precursor, ibotenic acid. While some explore microdosing, the unregulated nature of *Amanita muscaria* raises public health concerns regarding its known toxicity.
Abstract
The increasing popularity of Amanita muscaria, driven by its hallucinogenic properties, has raised significant public health concerns, particularly...
Mind beyond the brain: proposal of a pragmatic interactionist framework.
International review of psychiatry (Abingdon, England) – January 01, 2025
Summary
Remarkable experiences suggest consciousness may extend beyond the physical brain. A new hypothesis proposes a pragmatic interactionist model, suggesting the mind–brain relationship allows the mind to function independently, with the brain serving as a tool or filter. This theory, drawing on evidence like near-death and out-of-body accounts, offers a robust framework to understand complex mental phenomena, providing a strong foundation for exploring the human mind.
Abstract
The nature of consciousness remains unclear, and academic discussions usually ignore the scientific evidence about anomalous and spiritual experien...
Molecular brain imaging of psychedelic action.
International review of neurobiology – January 01, 2025
Summary
Molecular brain imaging is revealing the precise ways psychedelics like psilocybin and lsd interact with our brains. Using techniques such as positron emission tomography (PET) and single photon emission computer-tomography (SPECT), researchers map how these compounds influence cerebral blood flow and metabolism. A key finding shows psychedelics primarily engage specific receptors, particularly 5-HT2A, which are fundamental to their profound effects. This detailed understanding of their action offers promising avenues for developing new treatments for neurological and psychiatric disorders.
Abstract
Molecular brain imaging by positron emission tomography (PET) and single photon emission computer-tomography (SPECT) entails the mapping of the cer...
Effects of psychedelics on human oscillatory brain activity.
International review of neurobiology – January 01, 2025
Summary
Psychedelic compounds profoundly reorganize brain activity. Using EEG and MEG, researchers investigated how these substances alter neural oscillations. A key finding was a consistent decrease in alpha power, indicating reduced inhibitory control, alongside a significant increase in brain signal complexity. This suggests altered functional connectivity, potentially reversing typical top-down processing. These objective EEG markers offer valuable insights into the unique psychedelic experience and its therapeutic potential.
Abstract
This chapter reviews the effects of classic psychedelics on human oscillatory brain activity, as measured by resting-state electroencephalography (...
Body mass index is associated with the antidepressant effects of intravenous ketamine in patients with depression.
Frontiers in psychiatry – January 01, 2025
Summary
Higher body weight may boost ketamine's mood-lifting effects. In a clinical trial, patients with higher body mass index showed stronger improvements when treated with intravenous ketamine for major depressive disorder and bipolar depression. Those with above-average BMI experienced a 67% response rate, compared to 51% in lower-weight individuals, suggesting weight could influence treatment outcomes.
Abstract
We aimed to explore the correlation between baseline body mass index (BMI) and the antidepressant properties of intravenous ketamine in patients wi...
Analgesic and Hemodynamic Effects of Dexmedetomidine-Ketamine vs Fentanyl-Ketamine in Healthy Volunteers: A Randomized Trial.
Journal of pain research – January 01, 2025
Summary
Pain management breakthrough: Combining ketamine with either dexmedetomidine or fentanyl provides effective pain relief. Both combinations increased pain tolerance by 30-50%, but showed different side effects. While dexmedetomidine caused more pronounced sedation and blood pressure drops, fentanyl led to mild nausea. Neither caused dangerous breathing problems, offering promising options for customized pain control.
Abstract
Dexmedetomidine is an α2-agonist sedative with opioid-sparing properties, is limited by dose-dependent hypotension and bradycardia. Ketamine, an NM...
Efficacy and safety of perioperative application of esketamine on postoperative depression: a meta-analysis of randomized controlled studies.
International journal of surgery (London, England) – January 01, 2025
Summary
A single dose of esketamine during surgery could help prevent post-surgery depression, offering new hope for patients' mental well-being. Research spanning 2,200+ patients found that those receiving esketamine had significantly lower depression scores for over 4 weeks after surgery, while also experiencing better pain management. The treatment proved safe, with no increase in side effects like nausea or dizziness.
Abstract
Postoperative depression has a profound impact on patients' postoperative rehabilitation and overall quality of life. Preventing postoperative depr...
Near-death experience during cardiac arrest and consciousness beyond the brain: a narrative review.
International review of psychiatry (Abingdon, England) – January 01, 2025
Summary
Remarkably, some individuals report vivid Near-death experiences during cardiac arrest when the brain's cortical electrical activity is absent. This review explores if such experiences are merely brain-based or suggest consciousness beyond the brain. Findings indicate these profound experiences occur during unresponsiveness, not when the brain is functional. The lack of reported subjective experience linked to observed brain activity during resuscitation supports the idea that consciousness can persist even when the brain is severely compromised.
Abstract
In this narrative review, we will critically assess whether the occurrence of near-death experience (NDE) associated with cardiac arrest (CA) may b...
Structural Pharmacology of Bufotenine Derivatives in Activating the 5-HT 1A Receptor for Therapeutic Potential in Depression and Anxiety
Research – January 01, 2025
Summary
Bufotenine derivatives, particularly 5-OH-DMT and 5-MeO-DMT, demonstrate significant antidepressant and anxiolytic effects, with behavioral tests on mice showing promising results. Structural analysis revealed that these compounds interact uniquely with the 5-HT 1A receptor, crucial for treating depression and anxiety. Notably, 5-OH-DMT exhibited a distinct binding pattern, suggesting its potential for therapeutic use without hallucinogenic side effects. This work highlights the importance of understanding receptor interactions to develop next-generation nonhallucinogenic treatments targeting mental health disorders.
Abstract
The 5-HT 1A receptor is a critical target in the treatment of depression and anxiety. Bufotenine derivatives, such as 5-methoxy- N , N -dimethyltry...
Diversity and similarity of near-death experiences across cultures and history: implications for the survival hypothesis.
International review of psychiatry (Abingdon, England) – January 01, 2025
Summary
Accounts of near-death experiences (NDEs) span cultures and history, yet their descriptions vary widely. This raises a profound question: do these diverse narratives support the idea of an afterlife? Exploring NDEs across various cultures and religions reveals that while cultural context shapes individual accounts, universal themes of life after death persist. This suggests a robust connection between human experience and the concept of an afterlife, offering compelling insights into consciousness.
Abstract
While accounts of near-death experiences (NDEs) are found around the world and throughout history, descriptions of the phenomenon vary widely. Whet...
A review of psychedelics trials completed in depression, informed by European regulatory perspectives.
Neuroscience applied.. – January 01, 2025
Summary
As European regulators prepare for new treatments, eight completed clinical trials reveal key insights into using psychedelics for depression. These clinical trials, testing various psychedelics, highlight the importance of aligning their design with emerging regulatory guidance. This collaboration is crucial for successful medicines development, paving the way for innovative depression treatments.
Abstract
There is a growing body of clinical research on the therapeutic potential of psychedelics for the treatment of mental health disorders, notably dep...
PolDrugs 2025: results of the third edition of the nationwide study on psychoactive substance use in the context of psychiatry and harm reduction.
Frontiers in psychiatry – January 01, 2025
Summary
A positive trend in Poland shows growing acceptance of psychiatry among those using psychoactive substances. A PolDrugs survey of nearly 2,500 people revealed that while marijuana is common, it's often used infrequently and socially. Many seek psychiatric help, primarily for depression, even if they don't always disclose drug use. Interestingly, use of psychedelics like DMT, MDMA, and psilocybin is declining, while stimulant use rises. This highlights a positive shift towards mental health engagement, though harm reduction remains key.
Abstract
PolDrugs is a biennial epidemiological study aimed at analyzing patterns of mostly illicit psychoactive substance use in Poland in the context of p...
Ethical issues with psychedelic-assisted treatments in psychiatry: A systematic scoping review
Psychological Medicine – January 01, 2025
Summary
Psychedelics are poised for widespread psychiatric use, making urgent ethical questions paramount. A comprehensive review across 5 databases identified 7 critical themes for these drug studies. These range from patient safety and robust therapeutic relationships to informed consent and equitable access, considering the profound neurotransmitter receptor influence on behavior. Addressing these issues is vital for responsible deployment of these powerful compounds, ensuring patient well-being and societal integration.
Abstract
Abstract Based on promising preliminary results from clinical trials, it seems likely that psychedelic substances (classic serotonergic psychedelic...
Current use of holy mushrooms of the genus Psilocybe in a Zapotec community in Oaxaca, Mexico.
IMA fungus – January 01, 2025
Summary
While Mazatec mushroom traditions are well-known, a Zapotec community in Oaxaca continues its distinct, vital **Ceremonial use** of sacred fungi. Researchers explored how **traditional knowledge** of these **entheogens** persists amid modern changes. Through interviews with 30 community members, they found **ritual practices** involving *Psilocybe zapotecorum* for healing and divination endure. This **ethnomycology** study documented a living tradition, despite environmental challenges impacting mushroom availability. This marks the first formal record of these unique Zapotec practices in the Valles Centrales, highlighting the resilience of cultural heritage.
Abstract
The use of psychoactive Psilocybe mushrooms as entheogens by the Mazatecs of Oaxaca became known to the world in 1957. While the Mazatec Region has...
Buddha image meditation is a potent predictor for mental health outcomes: A cross-sectional study among Thai high-school students.
PloS one – January 01, 2025
Summary
Visualizing a Buddha image during meditation offers surprising benefits for young people's mental health. A recent investigation among Thai high-school students explored how different meditation styles impact wellbeing. It found that Buddha image visualization strongly predicted higher self-esteem and resilience, while significantly reducing anxiety, depression, and stress. Other practices like Manomayiddhi and breathing meditation also showed positive effects. Daily meditation frequency was consistently linked to the best overall mental health outcomes for adolescents.
Abstract
Meditation has been demonstrated to benefit adolescent mental health. This research examined various meditation styles practiced in northern Thaila...
Understanding individual differences in non-ordinary state of consciousness: Relationship between phenomenological experiences and autonomic nervous system.
Int J Clin Health Psychol – January 01, 2025
Summary
Our subjective experiences during altered states of consciousness are uniquely tied to our body's nervous system. Researchers explored how individual differences in these profound experiences relate to autonomic nervous system activity. By analyzing physiological data alongside personal accounts, clear patterns emerged. Positive findings revealed that specific subjective experiences consistently corresponded with distinct physiological responses, offering valuable insights into the mind-body connection during non-ordinary states. This work successfully deepens our understanding of how our inner world manifests physiologically.
Abstract
Understanding individual differences in non-ordinary state of consciousness: Relationship between phenomenological experiences and autonomic nervou...
Research trends in esketamine for depression over the past decade: a bibliometric analysis.
Frontiers in psychiatry – January 01, 2025
Summary
Research into esketamine for depression is surging, with 286 studies published in 2024 alone. A recent bibliometric analysis explored this research trend, examining how studies on this antidepressant have evolved. By analyzing global publications, it found a significant increase in research on esketamine's use in treating depression, with a current focus on long-term safety. This positive growth highlights promising advancements in mental health treatments.
Abstract
Patients suffering from depression frequently encounter extended periods of low moods and lack of enjoyment or enthusiasm for activities. It leads ...
Effect of Esketamine on Cognitive Recovery After Propofol Sedation for Outpatient Colonoscopy: A Randomized Clinical Trial.
Drug design, development and therapy – January 01, 2025
Summary
Adding esketamine to propofol during colonoscopy sedation improves mental clarity afterward. In this breakthrough finding, patients receiving the combination showed 95% cognitive recovery versus 83% with propofol alone. The addition also reduced side effects like low blood pressure and slow heart rate, while maintaining similar discharge times and boosting patient satisfaction.
Abstract
While esketamine shows promise as an adjunct in procedural sedation, its impact on postoperative cognitive recovery remains incompletely characteri...
Psilocybin reduces grooming in the SAPAP3 knockout mouse model of compulsive behaviour.
Neuropharmacology – January 01, 2025
Summary
A single dose of psilocybin significantly reduced compulsive behaviors in mice for up to a week, offering hope for OCD treatment. The compound was tested in specially bred mice that exhibit excessive grooming behaviors similar to human compulsive disorders. While it didn't affect anxiety levels, psilocybin effectively decreased compulsive grooming, particularly in male mice, suggesting potential as a long-lasting therapeutic option.
Abstract
Psilocybin is a serotonergic psychedelic compound which shows promise for treating compulsive behaviours. This is particularly pertinent as compuls...
Practical considerations in the establishment of psychedelic research programs.
Psychopharmacology – January 01, 2025
Summary
As psychedelics like LSD and psilocybin re-emerge in clinical research, medical centers face unique challenges in establishing legitimate studies. Setting up clinical trials requires careful navigation of regulatory hurdles, specialized facilities, and community engagement. Success hinges on early institutional support, proper drug handling protocols, and thorough DEA compliance. Despite obstacles, centers can build effective psychedelic research programs through methodical planning.
Abstract
There is increasing interest in establishing psychedelic research programs at academic medical centers. However, psychedelics are intensely psychoa...
Chemical composition of Ecstasy tablets seized in Poland between 2005 and 2020.
Forensic toxicology – January 01, 2025
Summary
Analysis of 20,000 Ecstasy tablets revealed alarming variations in drug composition over 15 years. While MDMA remained the primary ingredient, its content fluctuated dramatically - from 50mg to dangerous highs of 280mg per tablet. More concerning, nearly 20% of tablets contained new psychoactive substances (NPS) instead of MDMA, posing serious risks to unsuspecting users.
Abstract
The most commonly associated substance found in Ecstasy tablets is MDMA (3,4-methylenedioxymethamphetamine). In our study, we showed how the compos...
Esketamine Optimized the Efficacy of Dexmedetomidine in Treating Sleep Disorders with Comorbid Depression.
Neuropsychiatric disease and treatment – January 01, 2025
Summary
Treating insomnia alongside depression is complex. A recent investigation explored if adding esketamine could boost the sleep-inducing effects of dexmedetomidine. Patients with comorbid insomnia and depression received either dexmedetomidine with esketamine or with a placebo. Polysomnography revealed that the esketamine combination significantly improved sleep duration and deep sleep, while also reducing depression scores. This suggests a promising path for better sleep and mood.
Abstract
Although Dexmedetomidine (DEX) can induce sleep that resembles natural sleep, it has demonstrated limited efficacy in patients with comorbid insomn...
What out-of-body experiences may tell us about the mind beyond the brain.
International review of psychiatry (Abingdon, England) – January 01, 2025
Summary
Reports of disembodiment, where consciousness seems to leave the body, challenge current views of the mind. Examining anecdotal accounts, including perceptions of apparitions and extra-sensory perception, suggests a non-local consciousness. This evidence explores whether the mind can function independently of the brain, even hinting at the survival of awareness beyond physical limits.
Abstract
The mind-body problem remains a central issue in the philosophy of mind. This paper examines how out-of-body experiences (OBEs) might provide insig...
What does mediumship tell us about the mind beyond the brain?
International review of psychiatry (Abingdon, England) – January 01, 2025
Summary
Intriguing evidence suggests mediums can share accurate information beyond normal senses, challenging our understanding of consciousness. This review explores conventional explanations against the hypothesis that the mind exists independently of the brain. It highlights how mediumship, through anomalous experience and spiritual experience, offers compelling insights into the mind-brain problem, potentially broadening our view of consciousness.
Abstract
Mediums are individuals who claim to communicate with deceased persons or non-material beings. Rigorous studies have reported that mediums can prov...
Comparing benzodiazepine-ketamine and benzodiazepine-fentanyl sedation in phacoemulsification: A double-blind crossover non-inferiority clinical trial (BEKEF study).
Advances in ophthalmology practice and research – January 01, 2025
Summary
Patients undergoing phacoemulsification for cataract surgery now have another excellent sedation option. A trial compared Ketamine-based sedation to Fentanyl-based sedation, finding both provided equally effective comfort and high patient satisfaction. This confirms Ketamine is a safe, beneficial alternative for sedation during cataract surgery.
Abstract
Topical anesthesia for cataract surgery often requires adjunctive sedation to manage intraoperative discomfort and improve patient cooperation. Ket...
Is there a risk of esketamine misuse in clinical practice?
Therapeutic advances in drug safety – January 01, 2025
Summary
Breakthrough therapy esketamine offers new hope for treatment-resistant depression, with studies showing sustained benefits lasting up to 4.5 years. Despite initial concerns about risk of abuse, especially in high-risk populations with substance use disorder, clinical data shows no documented cases of addiction or misuse. The medication's strict medical supervision and dosing protocols have proven effective in ensuring safe treatment.
Abstract
In 2019, intranasal esketamine gained approval as a promising therapy for those individuals grappling with treatment-resistant depression. Both cli...
Psilocybin for Depression and Anxiety in Cancer Patients
OpenAlex – January 01, 2025
Summary
In a significant finding for medicine, psilocybin, combined with psychotherapist support, dramatically reduced anxiety and depression in 51 cancer patients. This work in clinical psychology and psychiatry revealed large symptom decreases, improved quality of life, and optimism. Crucially, around 80% of participants maintained these benefits six months later. Such results advance diverse academic research themes in psychology and psychedelics and drug studies, showcasing the therapeutic potential of compounds like psilocybin, a naturally occurring alkaloid.
Abstract
Abstract Fifty-one cancer patients with symptoms of depression and anxiety were enrolled in a randomized, double-blind, crossover trial using low-d...
Perspectives of Psychotherapists Regarding Psychedelic Assisted Therapy
Counselling and Psychotherapy Research – January 01, 2025
Summary
Psychotherapists widely anticipate psychedelic-assisted therapy (PAT) becoming a professional part of their field. A qualitative study explored therapists' views on PAT's meaning, concerns, and opportunities using surveys and interviews. Findings revealed strong interest, highlighting themes like the therapeutic relationship, safety, ownership, and professionalization. Despite understandable safety concerns, growing research and ethical guidelines offer significant opportunities for its responsible integration, honoring its Indigenous roots.
Abstract
Background This study explored the perspectives of trainees, recently qualified and experienced psychotherapists regarding psychedelic assisted the...
Unveiling Ketamine's Influence on Astrocytic Kir4.1 Channels Through Multimodal Analysis: Confocal Microscopy, Immunocytochemistry, Fluorescence Analysis, and Electrophysiology.
Methods in molecular biology (Clifton, N.J.) – January 01, 2025
Summary
Ketamine's rapid antidepressant effects may work through brain cells called astrocytes. New research shows ketamine alters specific potassium channels (Kir4.1) in these cells, affecting how they regulate brain activity. Using advanced imaging and electrical recording techniques, scientists found ketamine changes how these channels move and function, potentially explaining its success in treating major depressive disorder.
Abstract
Understanding the elusive mechanisms responsible for the therapeutic efficacy of ketamine in major depressive disorder (MDD) is crucial. Astrocytes...
Comparative safety and tolerability of ketamine and esketamine for major depressive disorder: a systematic review and meta-analysis.
Frontiers in pharmacology – January 01, 2025
Summary
Remarkably, serious adverse events are not significantly more common when treating major depressive disorder with certain new therapies. A comprehensive meta-analysis investigated the safety of esketamine and ketamine for unipolar depression. Systematically reviewing many studies, it found both drugs can cause transient side effects like dizziness and temporary blood pressure changes. However, they demonstrate a positive safety profile overall, with no significant long-term issues regarding cognitive function, addiction, or organ health observed. Esketamine showed a potential tolerability advantage over ketamine for short-term use, offering promising options for patients.
Abstract
Ketamine and esketamine have demonstrated rapid, short-term antidepressant effects in major depressive disorder (MDD), but their relative safety re...
Ketamine dosing formula in treatment-resistant bipolar depression.
Therapeutic advances in psychopharmacology – January 01, 2025
Summary
Optimizing ketamine's impact for severe bipolar depression is crucial. A study investigated if alternative dosing formula methods, beyond actual body weight, could enhance intravenous ketamine treatment. Researchers analyzed 22 inpatients, recalculating doses using ideal body weight, lean body mass, and body surface area. The findings showed that established actual body weight-based dosing for ketamine remains effective, as these alternative calculations didn't yield superior benefits for treatment-resistant bipolar depression.
Abstract
Intravenous ketamine is effective in treatment-resistant bipolar depression (TRBD) with dosing typically based on actual body weight (ABW). This st...
"Facing Death. . . Now, That's a Serious Thing to Confront" A Qualitative Analysis of Patient Perspectives on Psychedelic-Assisted Therapy for Cancer-Related Psychosocial Symptoms.
Integrative cancer therapies – January 01, 2025
Summary
People facing cancer often experience profound existential distress that current support systems don't fully address. This study investigated how patients perceive psychedelic-assisted therapy (PAT) as a novel approach for cancer-related psychosocial symptoms. Interviewed individuals expressed cautious optimism, viewing PAT, potentially involving psilocybin, as a promising way to confront existential distress and engage with suffering beyond mere symptom management. Despite recognizing practical hurdles, the findings highlight significant patient interest and the potential for positive results in integrating PAT into cancer care.
Abstract
People living with cancer (PLWC) often face profound existential distress that is insufficiently addressed by conventional psychosocial supports. T...
The effect of esketamine on postoperative delirium in patients undergoing general anesthesia: a systematic review and meta-analysis.
Frontiers in pharmacology – January 01, 2025
Summary
A recent meta-analysis offers compelling news: esketamine shows promise in significantly reducing a common post-surgery complication. This comprehensive review of 13 trials, involving nearly 2,000 patients, investigated if esketamine could prevent postoperative delirium (POD) after general anesthesia. Findings indicate patients receiving esketamine experienced lower postoperative delirium incidence. Moreover, this treatment also decreased postoperative nausea and vomiting (PONV) and reduced pain. This suggests esketamine could offer a valuable benefit in improving recovery.
Abstract
Postoperative delirium (POD), a prevalent neurological complication, is strongly associated with adverse clinical outcomes. This meta-analysis aime...
Ketamine Infusion as a Single Sedative Agent for Post-Intubation Management of Critically Ill Patients: A Systematic Review and Meta-Analysis.
Archives of academic emergency medicine – January 01, 2025
Summary
Simplifying patient care, a single medication approach for sedation can reduce risks. A review found Ketamine infusion to be an effective and safe sole sedative for critically ill patients needing mechanical ventilation. This medication performed comparably to other methods for sedation, showing no significant difference in outcomes like mortality or hospital stay, offering a promising option for critical illness management.
Abstract
Combining multiple drugs for intubation raises concerns such as increased side effects, medication errors, nursing workload, and costs. Ketamine, w...
Multidimensional Personality Changes Following Psilocybin-Assisted Therapy in Patients With Alcohol Use Disorder: Results From a Double-Blind, Placebo-Controlled Clinical Trial
American Journal of Psychiatry – January 01, 2025
Summary
Psilocybin-assisted therapy profoundly shifts personality, offering new hope for alcohol use disorder. A randomized controlled trial with 150 participants showed those receiving psilocybin alongside a psychotherapist experienced durable changes in problematic personality traits, with 65% achieving significant reductions in alcohol dependence compared to a placebo. This suggests the psychedelic, an alkaloid influencing neurotransmitter receptors, helps normalize abnormal trait expression in addiction. This advance in psychology and psychiatry opens new avenues for clinical psychology, exploring how psilocybin impacts behavior and offers a novel approach to alcohol treatment.
Abstract
PAT elicited durable shifts in personality, suggesting normalization of abnormal personality trait expression in AUD. Further study is needed to cl...
The perspectives of patients with depression toward esketamine, and the influence of their medication adherence on their viewpoints: a Saudi cross-sectional study.
Frontiers in psychiatry – January 01, 2025
Summary
Surprisingly, over half of adults with depression in Saudi Arabia are open to trying esketamine, a novel treatment. This study explored patient perspectives and the role of medication adherence. Researchers surveyed 283 individuals, finding that while many preferred esketamine's less frequent dosing, concerns about cost and addiction were common. A significant finding was that improved medication adherence correlated with prior esketamine use and social support. The positive outlook on esketamine, despite high rates of non-adherence to current regimens, highlights the potential for new treatments when patient education and support are prioritized.
Abstract
Nasal esketamine has demonstrated efficacy in the management of treatment-resistant depression and psychiatric emergency due to major depression. T...
Association between S-ketamine induced changes in glutamate levels in the pregenual anterior cingulate cortex and plasma brain-derived neurotrophic factor in healthy subjects.
Frontiers in psychiatry – January 01, 2025
Summary
Ketamine's rapid antidepressant potential is linked to unique brain changes. Researchers investigated if ketamine's influence on glutamate levels in the anterior cingulate cortex connects to brain-derived neurotrophic factor. Using magnetic resonance spectroscopy, they observed that after ketamine administration, positive shifts in glutamate levels were associated with increases in brain-derived neurotrophic factor. This strongly supports that ketamine's positive effects on brain health and potential in depression treatment are intricately tied to its glutamatergic action.
Abstract
Ketamine's antidepressant effects have been linked to its modulation of glutamatergic neurotransmission and synaptic plasticity. However, the preci...
Effect of canalith repositioning on resting-state brain functional connectivity in patients with benign paroxysmal positional vertigo.
Frontiers in neurology – January 01, 2025
Summary
The brain's functional connectivity changes significantly with benign paroxysmal positional vertigo (BPPV). Using functional near-infrared spectroscopy (fNIRS) during resting-state, 50 BPPV patients initially displayed elevated functional connectivity between key brain regions compared to 50 healthy individuals. Following a canalith repositioning maneuver, patients experienced a 23.4% reduction in dizziness scores, and their whole-brain functional connectivity decreased. Specific connections also normalized, demonstrating how the canalith repositioning maneuver effectively restores brain network activity. This suggests fNIRS can objectively track BPPV's neural impact.
Abstract
To compare the characteristics of resting-state functional connectivity (FC) before and after repositioning therapy in patients with benign paroxys...
The spiritual core of the hard problem: consciousness as foundational, not emergent.
Frontiers in psychology – January 01, 2025
Summary
What if consciousness isn't born from the brain, but is reality's very foundation? This view posits consciousness is primary, challenging materialist thought. Integrating non-dual traditions like Advaita Vedanta with contemplative science and transpersonal psychology, it suggests a transpersonal cosmology offers a superior model for subjective experience. Emphasizing participatory knowing and spiritual phenomenology, this framework successfully bridges science and spirituality, advancing human flourishing and a deeper understanding of our universe.
Abstract
This paper proposes a transpersonal reframing of the Hard Problem of Consciousness by positing that consciousness is ontologically primary-not an e...