Psychedelic experiences are shaped by the interaction of the drug, the user's psychological state (set), and the environment (setting), not just by pharmacology. A causal pluralist theory holds that multiple valid explanations—pharmacological, neural, psychological, social, political, and historical—can account for how set and setting influence the experience. Concepts from enactive cognitive science help clarify how higher-level causes like psychological states and cultural practices work, but enactive science has not yet produced testable models. Predictive processing theory may fill that gap. A pluralist synthesis of enactive cognitive science and predictive processing could provide the best conceptual tools for understanding the psychedelic experience scientifically.
Self-transcendent experiences (STEs), such as flow states and mystical experiences, are profound shifts in cognition and consciousness with transformative potential. A proposed cognitive continuum framework, grounded in enactive cognitive science and complex dynamic systems, treats the embodied person embedded in their world as the unit of analysis. STEs reflect an enhancement of relevance realization—the organism's active engagement with its environment to adaptively frame its world—across increasingly global levels of cognitive organization. Destabilization and complexification are central processes, with entropy as their metric. The Entropy-Fluency hypothesis posits that increased entropy signals destabilization followed by increased fluency, bridging first-person subjective experiences with third-person scientific observations. STEs are dynamic, person-specific, and context-dependent phenomena requiring idiographic and transdisciplinary methods.