Association Between Lifetime Hallucinogen Use and Valvular Heart Disease: Findings from the All of Us Research Program
Journal of Psychoactive Drugs May 18, 2026 Kevin H. Yang, Miranda Rasmussen, Kush Bhatt et al. 1 citation
Lifetime use of hallucinogens (LSD, psilocybin, MDMA, ketamine, or PCP) is associated with a modest increase in the odds of valvular heart disease after accounting for sociodemographic factors and other health conditions. In a large US adult sample, 13.2% reported lifetime hallucinogen use. The unadjusted prevalence of VHD was lower among users (3.6%) than non-users (4.7%), but after adjustment the odds rose slightly (adjusted odds ratio 1.08). The authors call for longitudinal studies to confirm this exploratory finding.