Academic engagement with psychedelic studies has been limited and fragmented along traditional disciplinary lines. An interdisciplinary approach is essential for understanding the potential of psychedelics for human healing and flourishing, and for ensuring an inclusive, holistic, and sustainable evolution of the field. This paper explores the intersection of psychedelic studies and interdisciplinarity, calling for more interdisciplinary institutional and cultural approaches in academia.
Depression involves a wide range of biological changes, from gene variations to epigenetic modifications, not only serotonergic mechanisms. Therapy response to antidepressants is linked to epigenetic regulation of genes in the serotonergic system. Persistent depressive symptoms may involve stable molecular adaptations in the brain at the epigenetic level. Responses to psychotherapy for mood disorders correlate with epigenetic alterations, including in genes regulating the serotonergic and glutamatergic systems and the HPA axis. Ketamine's antidepressant effects may be linked to epigenetic alterations, and further exploration of BDNF's relation with ketamine in epigenetic signaling is warranted. Understanding these mechanisms may help gauge therapy efficacy and duration.